Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults

• DOI: 10.3389/fphys.2021.625950
• Publication Date: 2021-02-05T18:52:40Z
• Authors: Oscar Bergens; Andreas Nilsson; Konstantinos-Geor...; Fawzi Kadi
• Keywords: Sedentary lifestyle

The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring PA was conducted a population men ( n = 83; age: 67.4 ± 1.5; height: 178.7 6.6 cm; weight: 80.9 10.6 kg) women 146; 1.6; 164.2 6.1 64.6 10.1 aged 65–70. Blood samples were collected for assessment inflammatory C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, monocyte chemoattractant protein-1 (MCP-1). Data analyzed using multiple linear regression models. Total bouts ≥10 min time inversely associated with marker IL-10 (accumulated time: β −0.116; bouts: −0.099; all p < 0.05). Associations independent moderate-to-vigorous (MVPA) total volume. In women, detrimentally pro-inflammatory fibrinogen −0.130; −0.085; remained accumulated adjusting MVPA This highlights routes by which on adults. findings support efforts promote accumulation spent at expense pursuits low-grade inflammation women.