NMDA Receptor Hypofunction in the Aging-Associated Malfunction of Peripheral Tissue

• DOI: 10.3389/fphys.2021.687121
• Publication Date: 2021-06-24T08:09:06Z
• Authors: Angélica Rivera-V...; Frida Higinio-Rod...; Laura Nava-Gómez; Bárbara Vázquez-P...; Isnarhazni Calero...; Rafael Olivares-M...; Mónica López-Hidalgo
• Keywords: 0303 health sciences; 03 medical and health sciences; Physiology; hypofunction of NMDA receptor; aging; QP1-981; glomerulus; D-serine; skin turnover; bone remodelling

Glutamatergic transmission through NMDA receptors (NMDARs) is important for the function of peripheral tissues. In bone, NMDARs and its co-agonist, D-serine participate in all phases remodeling. vasculature, exerts a tonic vasodilation decreasing blood perfusion corpus cavernosum filtration rate renal glomerulus. are relevant skin turnover regulating proliferation differentiation keratinocytes formation cornified envelope (CE). The interference with NMDAR leads to slow repair. As occurs brain cognitive functions, manifestations hypofunction resembles those observed during aging. This raises question if deterioration glomerular bone remodeling associated age could be related NMDARs. Furthermore, effects supplementation on these tissues, suggest that decrease account this pointing out as potential therapeutic target reduce or even prevent detriment tissue