Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys

• DOI: 10.3389/fphys.2021.690496
• Publication Date: 2021-06-25T05:48:50Z
• Authors: Yaya Xu; Xiangmei Kong; Jiru Li; Tiantian Cui; Yifan Wei; Jiayue Xu; Yueniu Zhu; Xiaodong Zhu
• Keywords: Hypoxia; Inflammatory response

Hypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that result the development renal interstitial fibrosis and subsequent chronic failure. Nonetheless, kidney possesses self-protection mechanism under certain degree hypoxia this its adaptation hypoxia. As hypoxia-inducible factor (HIF)-vascular endothelial growth (VEGF) axis is key pathway for neovascularization, activation target therapies.Sprague-Dawley rats were exposed normobaric subdivided into three groups, namely group A (21% O2), B (10% C (7% O2). Renal tissue samples processed analyzed determine pathological morphological changes, expression HIF, VEGF, inflammation vascular density.We found as duration increased, destructive changes tissues became more severe In contrast, increased did not exacerbate damage was prolonged HIF-1α gradually. time VEGF gradually, but O2) highest. Group had higher levels IL-6, IL-10, TNF-alpha. Additionally, highest density observed B.These findings suggest activating HIF-VEGF signaling regulate angiogenesis after infliction hypoxic injury may provide clues novel CKD treatments.