Association of Plasma Metabolic Biomarker Sphingosine-1-Phosphate With Cerebral Collateral Circulation in Acute Ischemic Stroke

• DOI: 10.3389/fphys.2021.720672
• Publication Date: 2021-08-19T08:34:26Z
• Authors: Fang Yu; Xianjing Feng; Xi Li; Zeyu Liu; Di Liao; Yunfang Luo; Minping Wei; Qin Huang; Lin Zhang; Jian Xia
• Keywords: Sphingolipid; Collateral circulation; Stroke

Background: The contribution of metabolic profile to the cerebral collateral circulation in acute ischemic stroke (AIS) has not been fully outlined. In this study, we conducted a metabolomic study assess relationship between biomarkers and status AIS. Methods: A two-stage was from September 2019 June 2021 our hospital. There were 96 subjects including 66 patients with AIS 30 healthy controls discovery stage 80 53 27 validation stage. Collateral assessed by Tan score based on computed tomographic angiography (CTA). Liquid chromatography-tandem mass spectrometry used identify differential markers. Then, an ELISA employed detect plasma levels sphingosine-1-phosphate (S1P). Results: 114 metabolites control groups 37 good (GCC) poor (PCC) groups. pathway enrichment analysis revealed that arginine biosynthesis only statistically significant sphingolipid metabolism GCC PCC sphinganine-1-phosphate (SA1P) S1P belong metabolism. stage, when group compared group, receiver operating characteristic (ROC) showed SA1P relative demonstrated area under curve (AUC) 0.719 (95% CI: 0.582–0.834), AUC 0.701 0.567–0.819). addition, both negative correlations 90-day modified Rankin Scale (mRS) score. sample, higher independent predictors ( p = 0.014), 0.738 0.599–0.849) differentiate PCC. also mRS Conclusion: We first illustrated association profiles Plasma might be potential diagnostic biomarker for predicting