Voluntary wheel exercise training affects locomotor muscle, but not the diaphragm in the rat

• DOI: 10.3389/fphys.2022.1003073
• Publication Date: 2022-10-26T06:33:21Z
• Authors: Anna A. Borzykh; Dina K. Gaynullina; Anastasia A. Shve...; Oxana O. Kiryukhina; Ilya V. Kuzmin; Ekaterina K. Seli...; Alexey M. Nesterenko; Olga L. Vinogradova; Olga S. Tarasova
• Keywords: Endurance Training; Diaphragm (acoustics); sed; Diaphragm muscle; Treadmill

Introduction: Functional tests and training regimens intensity-controlled by an individual are used in sport practice, clinical rehabilitation, space medicine. The model of voluntary wheel running rats can be to explore molecular mechanisms such humans. Respiratory locomotor muscles demonstrate diverse adaptations treadmill exercise, but the effects exercise on these muscle types have not been compared yet. Therefore, this work aimed at ET rat triceps brachii diaphragm with special attention reactive oxygen species, which regulate plasticity during exercise. Methods: Male Wistar were distributed into trained (ET) sedentary (Sed) groups. group had free access wheels, activity was continuously recorded analyzed using original hardware/software complex. After 8 weeks, protein contents studied Western blotting. Results: increased heart ventricular weights decreased visceral/epididymal fat blood triglyceride level Sed. did change corticosterone, testosterone, thyroid hormone levels, TBARS content blood. demonstrated higher OXPHOS complexes muscle, diaphragm. SOD2 increased, NOX2 SOD3 rats, while there no changes Conclusion: Voluntary is intensive enough govern specific fibers locomotor, respiratory muscle.