Chemokine-like receptor 1 plays a critical role in modulating the regenerative and contractile properties of muscle tissue

• DOI: 10.3389/fphys.2022.1044488
• Publication Date: 2022-11-17T07:08:59Z
• Authors: Julian Boesch; Eliane Pierrel; Christian Lambert; Arno Doelemeyer; Julie Kreider; Nathalie Accart; Serge Summermatter
• Keywords: endurance; satellite cells; 0303 health sciences; 03 medical and health sciences; Physiology; QP1-981; skeletal muscle; strength; chemerin; 3. Good health

Musculoskeletal diseases are a leading contributor to mobility disability worldwide. Since the majority of patients with musculoskeletal present associated muscle weakness, treatment approaches typically comprise an element resistance training restore physical strength. The health-promoting effects exercise mediated via complex, multifarious mechanisms including modulation systemic and local inflammation. Here we investigated whether targeted inhibition chemerin pathway, which largely controls inflammatory processes chemokine-like receptor 1 (CMKLR1), can improve skeletal function. Using genetically modified mice, demonstrate that blockade CMKLR1 transiently increases maximal strength during growth, but lastingly decreases endurance. In-depth analyses underlying long-term adaptations revealed microscopic alterations in number Pax7-positive satellite cells, as well molecular changes genes governing myogenesis calcium handling. Taken together, these data provide evidence critical role for regulating function by modulating regenerative contractile properties tissue. antagonists increasingly viewed therapeutic modalities variety (e.g., psoriasis, metabolic disorders, multiple sclerosis). Our findings thus have implications development novel drug substances aim at targeting pathway or other diseases.