Integrated Metabolomic and Lipidomic Analysis in the Placenta of Preeclampsia

Glycerophospholipids Lipidome
DOI: 10.3389/fphys.2022.807583 Publication Date: 2022-02-04T06:54:15Z
ABSTRACT
Preeclampsia is one of the most common severe pregnancy complications in obstetrics, which considered a placental source disease. However, mechanisms underlying preeclampsia remain largely unknown. In this study, UPLC-MS/MS-based metabolomic and lipidomic analysis was used to explore characteristic metabolites preeclampsia. The results revealed that there were significant changes between normotensive placentas. Weighted correlation network (WGCNA) identified module highly related clinical traits reflecting disease severity. metabolic perturbations primarily associated with glycerophospholipid glutathione metabolism, might influent membrane structures organisms mitochondria function. Using linear models, three had an area under receiver operating curves (AUROC) ≥ 0.80 lipids AUROC 0.90. Therefore, metabolomics lipidomics may offer novel insight for better understanding provide useful molecular mechanism
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