Integrated Metabolomic and Lipidomic Analysis in the Placenta of Preeclampsia

• DOI: 10.3389/fphys.2022.807583
• Publication Date: 2022-02-04T06:54:15Z
• Authors: Lizi Zhang; Shilei Bi; Yingyu Liang; Lijun Huang; Yulian Li; Minshan Huang; Baoying Huang; Weinan Deng; Jingying Liang; Shifeng Gu; Jingsi Chen; Lili Du; Dunjin Chen; Zhijian Wang
• Keywords: Glycerophospholipids; Lipidome

Preeclampsia is one of the most common severe pregnancy complications in obstetrics, which considered a placental source disease. However, mechanisms underlying preeclampsia remain largely unknown. In this study, UPLC-MS/MS-based metabolomic and lipidomic analysis was used to explore characteristic metabolites preeclampsia. The results revealed that there were significant changes between normotensive placentas. Weighted correlation network (WGCNA) identified module highly related clinical traits reflecting disease severity. metabolic perturbations primarily associated with glycerophospholipid glutathione metabolism, might influent membrane structures organisms mitochondria function. Using linear models, three had an area under receiver operating curves (AUROC) ≥ 0.80 lipids AUROC 0.90. Therefore, metabolomics lipidomics may offer novel insight for better understanding provide useful molecular mechanism