The Effect of Blood Flow-Restricted Low Resistance Training on Microvascular Circulation of Myocardium in Spontaneously Hypertensive Rats

• DOI: 10.3389/fphys.2022.829718
• Publication Date: 2022-04-14T14:21:57Z
• Authors: Zhaowen Tan; Yan Zhao; Yuchan Zheng; Ying Pan
• Keywords: 0301 basic medicine; 03 medical and health sciences; hypertension; microvascular circulation; Physiology; myocardium; blood pressure; QP1-981; cardiac function; blood flow-restricted low resistance training

Objective: The purpose of this study was to explore the effect blood flow-restricted low resistance training on microvascular rarefaction in myocardium spontaneously hypertensive rats (SHRs). Methods: Four-week-old male SHRs were randomly divided into following groups: Wistar-Kyoto (WKY), SHR control (SHR-SED), high-intensity (HIRT), low-intensity (LIRT), and (BFRT). exercise groups began receive intervention for 8 weeks at age 7 weeks. Blood pressure (BP), heart rate (HR), cardiac function, capillary density, Vascular endothelial growth factor -Phosphatidylinositol 3-kinase-Protein kinase B-Endothelial nitric oxide synthetase (VEGF-Pi3k-Akt-eNOS) assessed. Results: 1) BP HR BFRT decreased significantly, Ejection fraction (EF) Fraction shortening (FS) increased, lowering better than that other (p < 0.05); 2) expression VEGF, VEGFR2, p-VEGFR2, Pi3k, Akt, p-Akt, eNOS p-eNOS significantly upregulated, higher 0 05); 3) VEGF SHR-SED, lower HIRT 0.05), there no significant difference between LIRT(p > 4) density 05). Conclusion: can activate VEGF-Pi3k-Akt-eNOS pathway, upregulate blood, improve rarefaction, promote myocardial circulation, thereby improving function pressure, achieving preventive early hypertension.