Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring

• DOI: 10.3389/fphys.2022.931147
• Publication Date: 2022-08-26T10:22:04Z
• Authors: Mercedes Gauthier; Antoine Brassard ...; Anna Polosa; Allison L. Dorfman; Cynthia X. Qian; Jean-Marc Lina; Pierre Lachapelle
• Keywords: Electroretinography; Erg; Stimulus (psychology); Scotopic vision; Photic Stimulation; Evoked potential; Retinal Disorder

The electroretinogram (ERG) represents the biopotential evoked by retina in response to a light stimulus. flash ERG (fERG) is modality most frequently used clinically diagnose and monitor retinal disorders. We hereby present new method record spontaneous activity, without use of stimulus, that we named resting-state (rsERG). recordings were done normal subjects under light- dark-adaptation with different background conditions (i.e., variations wavelength intensity). Additionally, rsERG obtained five patients retinopathies. signals subsequently analyzed frequency domain, extracting both periodic peaks) aperiodic trend) components signal. later was further assessed through multifractal analysis using Wavelet Leaders. Results show that, irrespective recording used, always includes same 90 Hz component; component also fERG response, suggesting retinally-intrinsic origin. However, addition, fERGs low-frequency which absent rsERGs, finding supporting retinally-induced Comparing rsERGs selected various disorders indicates two are not similarly affected (either as result underlying pathology or otherwise), an added value assessment function. Thus, could have similar role clinical visual electrophysiology EEG neurology namely, quantify changes activity from given disease processes.