Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease

• DOI: 10.3389/fphys.2023.1170537
• Publication Date: 2023-07-27T17:05:15Z
• Authors: Jia-Lin Li; Zhen Cai; Jing Zhao; Xiang-Gang Zhu; Qian Li; Yan-Shuang Li; Meng-Chao Liu; Fang-Qiang Cui; Wen-Jing Zhao; Wen-Quan Niu
• Keywords: nomogram; peritoneal dialysis; Physiology; Physiology (medical); Kt/V urea; QP1-981; anemia; chronic kidney disease; 3. Good health

Objectives: The study aimed to examine the association of three anemia-related biomarkers with adequacy peritoneal dialysis (PD) in patients chronic kidney disease (CKD). Methods: This included 127 PD patients. total Kt/V urea (Kt/V) was calculated according Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. All were classified into two groups based on Kt/V, viz., adequate (Kt/V ≥1.7) and inadequate <1.7) groups. Effect sizes are expressed as odds ratios (ORs) 95% confidence interval (CI). Results: After adjusting for age, gender, hypertension, diabetes, duration, 20 g/L increment hemoglobin (Hgb) observed significantly reduce risk by 19% (OR; CI; P: 0.81; 0.70 0.95; 0.009), 5 mean corpuscular concentration (MCHC) 7% (0.93; 0.88 0.98; 5% transferrin saturation (TS) 23% (0.77; 0.64 0.94; 0.012). gender-specific nomogram model constructed incorporating significant convenient influencing factors, prediction accuracy good (concordance index (C-index): 0.686 men 0.825 women). Conclusion: Our findings indicate that deterioration (Hgb, MCHC, TS) can precipitate development Chinese CKD.