Advances in metabolic reprogramming of renal tubular epithelial cells in sepsis-associated acute kidney injury

• DOI: 10.3389/fphys.2024.1329644
• Publication Date: 2024-01-19T04:34:39Z
• Authors: Tiantian Wang; Ying Huang; Xiaobei Zhang; Yi Zhang; Xiangcheng Zhang
• Keywords: 0303 health sciences; 03 medical and health sciences; renal tubular epithelial cells; Physiology; oxidative phosphorylation; metabolic reprogramming; QP1-981; glycolysis; sepsis-associated acute kidney injury

Sepsis-associated acute kidney injury presents as a critical condition characterized by prolonged hospital stays, elevated mortality rates, and an increased likelihood of transition to chronic disease. suppresses fatty acid oxidation oxidative phosphorylation in the mitochondria renal tubular epithelial cells, thus favoring metabolic shift towards glycolysis for energy production. This acts protective mechanism kidneys. However, extended reliance on may contribute atrophy, fibrosis, subsequent disease progression. Metabolic reprogramming interventions have emerged prospective strategies counteract sepsis-associated restoring normal function, offering potential therapeutic preventive modalities. review delves into alterations cells associated with injury, stressing importance immune response urgency normalization. We present various intervention targets that could facilitate recovery phosphorylation-centric metabolism. These novel insights aim transform clinical prevention treatment landscape focus mechanisms. investigation provide valuable clinicians aiming enhance patient outcomes context injury.