Piezo channels in the intestinal tract

• DOI: 10.3389/fphys.2024.1356317
• Publication Date: 2024-02-06T04:57:35Z
• Authors: Haolong He; Jingying Zhou; Xuan Xu; Pinxi Zhou; Huan Zhong; Mi Liu
• Keywords: Mechanotransduction; mechanosensation; Piezo1

The intestine is the largest mechanosensitive organ in human body whose epithelial cells, smooth muscle neurons and enteroendocrine cells must sense respond to various mechanical stimuli such as motility, distension, stretch shear regulate physiological processes including digestion, absorption, secretion, motility immunity. Piezo channels are a newly discovered class of ion consisting two subtypes, Piezo1 Piezo2. widely expressed involved pathological processes. present review summarizes current research progress on expression, function regulation intestine, with aim providing reference for future development therapeutic strategies targeting channels.