Subacute exposure to apigenin induces changes in protein synthesis in the liver of Swiss mice

• DOI: 10.3389/fphys.2025.1576310
• Publication Date: 2025-05-09T11:31:11Z
• Authors: Łukasz S. Jarosz; Katarzyna Socała; Katarzyna Michalak; Kamila Bulak; Artur Ciszewski; Agnieszka Marek; Zbigniew Grądzki; Piotr Wlaź; Edyta Kowalczuk-V...; Anna Rysiak
• Keywords: Parenchyma

Apigenin is a natural flavonoid with various pharmacological properties. Available data indicate that it affects the metabolic processes and protein profile of cells, including hepatocytes. However, there speculation use apigenin may have hepatotoxic effect. The aim experiment was to assess effect administered intraperitoneally mice on concentrations pro- anti-inflammatory cytokines in liver tissue analyse weight morphological changes parenchyma. A proteomic analysis also performed examine differences genes expression for specific proteins cells. Adult male albino Swiss were divided into two groups treated either (50 mg/kg BW) – APG, or vehicle (1% DMSO) CONT, every 24 h 14 days. material study consisted samples. Slight hepatocyte degeneration microscopically demonstrated most exposed apigenin. No significant observed absolute relative between control experimental group. mass spectrometry results significantly higher synthesis MAP2K19, CEP69, GNMT, BPIFA3, SYT17, ANKRD1, GRHPR, CLEC1A EF2 livers from APG group comparison CONT Exposure induces functional liver. In conjunction microscopical analyses, this inflammatory developing could be self-limiting subject regenerative processes.