Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents

• DOI: 10.3389/fpsyg.2024.1292071
• Publication Date: 2024-02-22T12:03:42Z
• Authors: Hengye Huang; Kelvin Pengyuan Z...; Karol Kexin Sun; Guangjun Yu
• Keywords: Association (psychology); Neurodevelopmental disorder

Evidence of the association certain neurodevelopmental disorder with specific type 2 inflammatory (T2) disease has been found. However, various disorders T2 diseases as a whole remains unclear in low-birth-weight (LBW) infants. To evaluate intellectual disability (ID), autism spectrum (ASD), attention deficit hyperactivity (ADHD), and learning (LD) LBW children adolescents. The study sample was derived from 2005 to 2018 National Health Interview Survey child files. adolescents aged 3-17 were included. History (including asthma atopic dermatitis) four reported by adults families. relationship between risk investigated through multiple-weighted logistic regression. Age, sex, race/ethnicity, region, highest education family ratio income poverty threshold adjusted covariates for model estimation. Subgroup analyses conducted age stratification (3-11 12-17 years), sex (male female), race (white non-white). 11,260 years [mean (SE), 9.73 (0.05) years] included, which 3,191 had diseases. associated an increased disorders, OR 1.35 (95% CI, 0.99-1.84) ID, 1.47 1.05-2.05) ASD, 1.81 1.51-2.16) ADHD, 1.74 1.49-2.04) LD following adjustment all covariates. correlations each significantly different (all P interaction < 0.001), no differences found > 0.05). In nationally representative children, we significant LD, even after adjusting demographic baseline. We also that differed race. Further investigation is needed causal relationships elucidate their potential mechanisms.