A Multi-Center Study on the Relationship Between Developmental Regression and Disease Severity in Children With Autism Spectrum Disorders

• DOI: 10.3389/fpsyt.2022.796554
• Publication Date: 2022-03-09T05:37:06Z
• Authors: Chaoqun Hu; Fan Yang; Ting Yang; Jie Chen; Ying Dai; Feiyong Jia; Lijie Wu; Yan Hao; Ling Li; Jie Zhang; Xiaoyan Ke; Mingji Yi; Qi Hong; Jinjin Chen; Shuanfeng Fang; Yichao Wang; Qi Wang; Chunhua Jin; Tingyu Li; Li Chen
• Keywords: Psychiatry; 05 social sciences; relationship; RC435-571; autism spectrum disorder; regression; disease severity; 0501 psychology and cognitive sciences; multi-center study; 10. No inequality; 3. Good health

This study aimed to investigate the prevalence of developmental regression in children with Autism Spectrum Disorder (ASD) and explore its relationship disease severity. We finally included 1,027 ASD aged 2-5 years from 13 cities China: 138 regressive 889 non-regressive ASD. The Social Responsiveness Scale (SRS), Behavior Checklist (ABC), Child Rating (CARS), Children Neuropsychological Behavioral Scale-Revision 2016 (CNBS-R2016) were used evaluate core symptoms status two groups. Among eventually included, (13.44%) cases showed behavior average occurring age was 24.00 (18.00-27.00) months. children, 105 (76.09%) had language regression, 79 (57.25%) social 4 (2.90%) motor regression. total scores ABC sub-score sensory stereotypic (β = 5.122, 95% CI: 0.818, 9.426, P < 0.05; β 1.104, 0.120, 2.089, 1.388, 0.038, 2.737, 0.05), SRS autistic mannerisms 4.991, 0.494, 9.487, 1.297, 0.140, 2.453, 0.05) group all higher than group. quotient (DQ) CNBS-R2016 DQ gross motor, fine adaptive behavior, -5.827, -11.529, -0.125, personal society lower proportion intelligent impairment Regressive autism is mainly manifested as have more severe symptoms, neurodevelopmental level DQ, serious degree ASD, which requires further etiological examinations clinical attention.