Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status

• DOI: 10.3389/fpsyt.2023.1039239
• Publication Date: 2023-03-08T06:30:35Z
• Authors: Julie Novakova Ma...; Maria Teresa Ferr...; Alberto Ferrari; Ondrej Lerch; Veronika Matuskova; Juraj Secnik; Jakub Hort
• Keywords: Apolipoprotein E

Introduction Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease. In this pilot study, we aimed to elucidate association between longitudinal changes CP volume, sex and cognitive impairment. Methods We assessed volume a cohort n = 613 subjects across 2,334 datapoints from ADNI 2 ADNI-GO, belonging cognitively unimpaired (CN), stable mild impairment (MCI), clinically diagnosed disease dementia (AD) or convertor (to either AD MCI) subgroups. was automatically segmented used as response variable linear mixed effect models with random intercept clustered by patient identity. Temporal effects select variables were interactions subgroup analyses. Results found an overall significant increase time (14.92 mm 3 per year, 95% confidence interval, CI (11.05, 18.77), p < 0.001). Sex-disaggregated results showed annual rate 9.48 males [95% (4.08, 14.87), 0.001], 20.43 females (14.91, 25.93), indicating more than double females, which appeared independent other temporal variables. The only diagnostic group compared CN convertors group, 24.88 /year (14, 35.82), 0.001]. ApoE exhibited effect, E4 homozygote group’s increasing at triple non-carrier heterozygote groups [40.72, (25.97, 55.46), 0.001 vs. 12.52, (8.02, 17.02), for homozygotes non-carriers, respectively], may modified relationship. Conclusion Our contribute potential differences novel finding twice choroid enlargement provide putative support CP-related deterioration its relationship E4.