Depression and risk of sarcopenia: a national cohort and Mendelian randomization study

• DOI: 10.3389/fpsyt.2023.1263553
• Publication Date: 2023-10-18T08:01:34Z
• Authors: Qian Zhong; Lisha Jiang; Kang An; Lin Zhang; Shuangqing Li; Zhenmei An
• Keywords: Mendelian Randomization; Depression

Background Depression and the increased risk of sarcopenia are prevalent among elderly population. However, causal associations between these factors remain unclear. To investigate potential association depression in older adults, this study was performed. Methods In baseline survey, a total 14,258 individuals aged 40 above from China Health Retirement Longitudinal Study (2015) participated. We initially described prevalence disease. Then, logistic regression restricted cubic spline (RCS) were conducted to assess relationship sarcopenia. Subgroup analysis performed validate robustness findings. Additionally, we Mendelian randomization using inverse variance weighting estimator Furthermore, adopted six methods, including MR-Egger, simple median, weighted maximum likelihood, robust adjusted profile score (RAPS), MR Pleiotropy Residual Sum Outlier (MR-PRESSO), for sensitivity analyses. Results patients exhibited higher risks all five models adjusting different covariates ( P < 0.05). The RCS demonstrated linear subgroup analysis, observed participants 60−70, married or cohabiting individuals, non-smokers, non-drinkers, those with less than 8 h sleep, BMI below 24, hypertension (all results revealed that genetically proxied led reduction appendicular skeletal muscle mass Conclusion Our provides observational evidences can lead This finding emphasizes importance timely identification management depression, as well implementing targeted educational programs part comprehensive strategies prevent