Effect of brain acidification on depression-related behaviors in diabetes mellitus

• DOI: 10.3389/fpsyt.2023.1277097
• Publication Date: 2023-11-29T05:52:06Z
• Authors: Yusuke Temma; Kisho Obi-Nagata; Yoshio Hoshiba; Ryuhei Miyake; Yuta Katayama; Hideo Hagihara; Norimitsu Suzuki; Tsuyoshi Miyakawa; Keiichi I. Nakayama; Akiko Hayashi-Takagi
• Keywords: Anhedonia; Depression

Major depressive disorder (depression) is a leading cause of disability. The severity depression affected by many factors, one which being comorbidity with diabetes mellitus (DM). DM major public health concern due to the high incidence both conditions and their mutually exacerbating pathophysiology. However, mechanisms exacerbates remain largely unknown, elucidating these regulatory would contribute significant unmet clinical need. We generated comorbid mouse model (comorbid model), was extensively compared models. Depressive anhedonic phenotypes were more severe in model. thus concluded that recapitulated exacerbated depression-related behaviors clinic. RNA sequencing analysis prefrontal cortex tissue revealed brain pH homeostasis gene set most Furthermore, negatively correlated anhedonia-related By contrast, correlations not detected or control group, neither had been exposed chronic stress. This suggested addition reduced stress-exposed synergistic aversive effects on phenotypes. Because strongly lactate level, blood glucose levels, findings highlight therapeutic importance glycemic only for DM, but also psychiatric problems patients DM.