Risk factors for suicidal attempts in a sample of outpatients with treatment-resistant depression: an observational study

• DOI: 10.3389/fpsyt.2024.1371139
• Publication Date: 2024-03-22T04:56:30Z
• Authors: Serena Chiara Civ...; Filippo Besana; Giovanni Carneval...; Filippo Mazzoni; Vincenzo Arienti; Pierluigi Politi; Natascia Brondino; Miriam Olivola
• Keywords: Depression

Introduction Treatment-resistant depression (TRD) is commonly defined as the failure of at least two trials with antidepressant drugs, given right dose and for an appropriate duration. TRD associated increased mortality, compared to patients a simple major depressive episode. This rate was mainly attributed death from external causes, including suicide accidents. The aim our study identify socio-demographic psychopathological variables suicidal attempts in sample outpatients TRD. Material methods We performed monocentric observational retrospective design 63 subjects referred Italian outpatient mental health centre. collected data interviews clinical records. Results 77.8% (N=49) were females, mean age 49.2 (15.9). 33.3% (N=21) had attempted suicide. 54% (N=34) psychiatric comorbidity. Among variables, substance use (p=0.031), comorbidities (p=0.049) high scores HAM-D (p=0.011) occurrence attempts. In regression model, (OR 6.779), 3.788) 1.057) predictive When controlling gender, only 6.114) maintained association Conclusion integrated treatment abuse, which involves different services, fundamental achieving recovery these patients. Our supports importance performing careful evaluation order factors risk