Exposure to Phenols, Phthalates, and Parabens and Development of Metabolic Syndrome Among Mexican Women in Midlife

• DOI: 10.3389/fpubh.2021.620769
• Publication Date: 2021-02-26T05:12:53Z
• Authors: Astrid N. Zamora; Erica C. Jansen; Marcela Tamayo-Ortiz; Jaclyn M. Goodrich; Brisa N. Sánchez; Deborah J. Watkins; Juan Alfredo Tama...; Martha M. Téllez-...; Adriana Mercado-G...; Ana Baylin; John D. Meeker; Karen E. Peterson
• Keywords: Abdominal obesity; Paraben

Background: Evidence suggests exposure to endocrine-disrupting chemicals (EDCs) can influence Metabolic Syndrome (MetS) risk in adults, but it is unclear if EDCs impact women during midlife. We examined measured adult were predictive of MetS and its components 9 years later. Methods: urinary phthalate metabolites, phenols, parabens collected 2008 among 73 females from the ELEMENT study. (Abdominal Obesity, Hypertriglyceridemia, Cholesterolemia, Hypertension, Hyperglycemia) assessed 2017. regressed log-transformed EDC concentrations on using logistic regression, adjusting for age physical activity. Results: At follow-up, mean (SD) was 46.6 (6.3) years; prevalence 34.3%. Sum dibutyl metabolites (ΣDBP), monobenzyl (MBzP), monoethyl (MEP) associated with an increased odds hypertriglyceridemia. 2,5-dichlorophenol (2,5 DCP) 2,4-dichlorophenol (2,4 The hypertension 4.18 (95% CI: 0.98, 17.7, p < 0.10) 3.77 0.76, 18.62, times higher every IQR increase MCOP propyl paraben, respectively. hyperglycemia 0.46 0.18, 1.17 lower sum di-2-ethylhexyl (ΣDEHP), abdominal obesity 0.70 0.40, 1.21, concentration triclosan. Conclusion: found marginally hypertriglyceridemia Results suggest that certain toxicants related markers metabolic midlife women.