Prevalence and clinical characteristics of methicillin-resistant Staphylococcus aureus infections among dermatology inpatients: A 7-year retrospective study at a tertiary care center in southwest China

• DOI: 10.3389/fpubh.2023.1124930
• Publication Date: 2023-03-14T06:00:25Z
• Authors: Zhijian Yao; Yidan Wu; Hongming Xu; Ying Lei; Wanyu Long; Meixian Li; Yue Gu; Zhiwen Jiang; Cunwei Cao
• Keywords: Staphylococcal Skin Infections; Linezolid

Background Increased rates of methicillin-resistant Staphylococcus aureus (MRSA) antibiotic resistance and the associated morbidity have increased dermatologists' attention to skin soft tissue MRSA infections. However, clinical characterization infections (SSTIs) in Southwest China is lacking, which precludes optimal prevention treatment these Objectives This study was conducted characterize prevalence, comorbidities susceptibility isolates from SSTIs, including community-associated (CA) healthcare-associated (HA) isolates. Methods In Dermatology Inpatient Department First Affiliated Hospital Guangxi Medical University, a retrospective on data, patient demographics information, culture-confirmed S. isolated between January 1, 2015, December 31, 2021. Isolate 13 antibiotics determined using Vitek 2 system. Results From among 864 strains, we identified 283 (32.75%) comprising 203 CA-MRSA 80 HA-MRSA The average rate isolation for SSTIs 71.73%. significantly. HA-MRSA-infected patients were older. most common dermatological presentation infection staphylococcal scalded syndrome, while comorbidity severe drug eruption significantly with infection. One strain resistant linezolid, one had an intermediate phenotype vancomycin; both strains low sensitivity clindamycin erythromycin (3.70%~19.40%). more susceptible trimethoprim/sulfamethoxazole. Conclusions predominant pathogen causing incidence increasing gradually. Both showed resistance. Our data may guide dermatologist decisions. Dermatologists should consider when are admitted initiate early MRSA.