The effects of ambient particulate matter air pollution on platelets and hemostasis

• DOI: 10.3389/fpubh.2024.1410406
• Publication Date: 2024-07-18T14:02:42Z
• Authors: Sasinee Hantrakool; Maitree Sriwichai; Banphot Shaengkha...; Nipapan Leetrakool; Piangrawee Niprapan; Sawaeng Kawichai; Sitapak Wannakul; Noppamas Panyasit; Pakinee Tuntivate; Ornkamon Wongtagan; Rungrote Natesiri...; Pimpisid Koonyosying; Phichayut Phinyo; Teerachat Punnachet; Nonthakorn Hantrakun; Pokpong Piriyakhu...; Thanawat Rattanat...; Chatree Chai-Adis...; Ekarat Rattaritta...; Adisak Tantiworawit; Lalita Norasetthada; Somdet Srichairat...
• Keywords: Prothrombin time

Introduction Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with balance of hemostatic system remain unclear. This study investigates PM-mediated changes in individuals across unique seasonal variations pollution. Methods prospective was conducted between February and July 2020 during alterations Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin (aPTT), von Willebrand factor (vWF), platelet count, functions, evaluated. A mixed-effects model used analyze impact high PM2.5 PM10 on parameters. Results Thirty male mean age 38.9 ± 8.2 years, included. High levels significantly associated PT shortening, no such effect observed aPTT. values also positively correlated vWF function, while antigen remained unchanged. Soluble P-selectin showed a strong positive association levels. Platelet function analysis revealed correlation PM values. Conclusion Short-term elevated concentrations shortened enhanced individuals. Exploring these clinically relevant thrombosis crucial. Additional studies pathogenesis pollution-related are warranted for maintaining good health.