The future of personalized cardiovascular medicine demands 3D and 4D printing, stem cells, and artificial intelligence

• DOI: 10.3389/fsens.2023.1294721
• Publication Date: 2023-12-05T05:01:52Z
• Authors: Monique Bax; Jordan Thorpe; Valentin Romanov
• Keywords: Personalized Medicine; Lab-on-a-Chip; Regenerative Medicine

Cardiovascular diseases remain the most lethal disorders worldwide. Employing preeminent techniques is paramount for addressing this global challenge. Recent advances in lab-on-a-chip technology have potential to transform cardiovascular medicine by providing new tools understanding biological variability that underlies disease and drug response. Coupling improved fabrication cellular models with artificial intelligence-based design analysis primes field model explore biology more accurately than ever before. The of systems has dramatically evolved development additive manufacturing technologies. Not only can 3D printing be used fabricate intricate microfluidic networks, but now through incorporation smart materials, 4D change shape properties devices based on external stimuli. By leveraging induced pluripotent stem cells, open opportunities within personalized medicine. As customizable systems, fabricated populated donor cell-derived cells mimic system. These capabilities are going improve increasingly important role intelligence centric design, real-time analysis, data gathering, processing analysis. Here, we address personalize lens devices, derived engineered vasculature heart tissues, how continues field.