Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

• DOI: 10.3389/ftox.2024.1465704
• Publication Date: 2024-10-24T05:10:51Z
• Authors: Christina Drake; Walter Zobl; Sylvia E. Escher
• Keywords: Gene co-expression network; Expression (computer science)

For many industrial chemicals toxicological data is sparse regarding several regulatory endpoints, so there a high and often unmet demand for NAMs that allow screening prioritization of these chemicals. In this proof concept case study we propose multi-gene biomarkers compounds' ability to induce lung fibrosis demonstrate their application