Investigation of COVID-19 virus mutagenicity and the effect of the NSP13, NSP14, and NSP16 on the -1 ribosomal frameshifting

• DOI: 10.3389/fviro.2024.1405680
• Publication Date: 2024-07-16T05:10:15Z
• Authors: Ali Khanifar; Azin Najafi; Jaber Hemmati; Fatemeh Nouri; Seyed Ali Hosseini; Mohammad Taheri
• Keywords: Translational frameshift; Coronavirus

The COVID-19 virus is a single-stranded from the Coronaviridae family and has genome of about 29881 bp, which causes acute respiratory disease. One way transmission respiratory, reason for significant mutagenesis in different parts with its mechanisms, including -1 ribosomal frameshifting. Various that have undergone most severe mutations include spike protein, leads to emergence new variants. Most observed are located S protein region known as RBD (Receptor-Binding Domain), binds ACE2 (Angiotensin-converting enzyme 2) receptor human cells. variations will determine how it receptor. Essentially, changes created because mutation affinity ACE2. On other hand, virus, NSP13, NSP14, NSP16 proteins, helps by consuming magnesium ions (Mg 2+ ). Since ribosome stable Mg , convert polysome monosome state, break translation finally formation