Pregnancy Complications and Impact on Kidney Allograft After Kidney Transplantation in IgA Nephropathy

• DOI: 10.3389/ti.2023.11220
• Publication Date: 2023-05-04T10:31:30Z
• Authors: Rikako Oki; Kohei Unagami; Jun Kakogawa; Hiroko Beppu; Taro Banno; Takafumi Yagisawa; Taichi Kanzawa; Toshihito Hirai; Kazuya Omoto; Kumiko Kitajima; Hiroki Shirakawa; Junichi Hoshino; Toshio Takagi; Hideki Ishida
• Keywords: Nephrology

Pregnancy in kidney transplantation (KT) recipients has been challenging because of the high risk maternal, fetal, and renal complications. Although patients with immunoglobulin A nephropathy (IgAN)-chronic disease (CKD) are at a for hypertension pregnancy (HIP), maternal KT IgAN as etiology remains unclear. We retrospectively reviewed medical records pregnant who delivered our hospital. The incidence fetal complications impact on allografts between group primary other diseases were compared. analysis included 73 pregnancies 64 recipients. had higher HIP than non-IgAN (69% vs. 40%, p = 0.02). interval from to conception associated (OR 3.33 [1.11-9.92], 0.03, OR 0.83 [0.72-0.96], < 0.01, respectively). 20-year graft survival or prevention CKD stage 5 was lower that (p 0.01). should be informed possibility long-term worsening postpartum function.