Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats

• DOI: 10.3390/antiox10010125
• Publication Date: 2021-01-18T10:17:34Z
• Authors: Sara Damiano; Consiglia Longobardi; Emanuela Andretta; Francesco Prisco; Giuseppe Piegari; Caterina Squillac...; Serena Montagnaro; Francesco Pagnini; Paola Badino; Salvatore Florio; Roberto Ciarcia
• Keywords: Nephrotoxicity

Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, immunotoxicity to both humans several animal species. The severity of the liver damage caused depends on dose duration exposure. Several studies have suggested that oxidative stress might contribute increasing hepatotoxicity OTA, antioxidants, including curcumin (CURC), been tested counteract toxic hepatic action OTA classes animals. Therefore, present study was designed evaluate protective effect CURC, bioactive compound with different therapeutic properties injuries by rat models. CURC effects were examined Sprague Dawley rats treated (100 mg/kg), alone or combination (0.5 gavage daily 14 days. At end experiment, showed alterations biochemical parameters liver. dosing significantly attenuated lipid peroxidation versus group. Furthermore, histological tests reduced multifocal lymphoplasmacellular hepatitis, periportal fibrosis, necrosis observed This provides evidence can preserve OTA-induced rats.