Platycodon grandiflorum Root Protects against Aβ-Induced Cognitive Dysfunction and Pathology in Female Models of Alzheimer’s Disease

• DOI: 10.3390/antiox10020207
• Publication Date: 2021-02-01T10:16:28Z
• Authors: Yunkwon Nam; Soo Jung Shin; Yong Ho Park; Min-Jeong Kim; Seong Gak Jeon; Hyewon Lee; Yeji Choi; Tae-Jin Kim; Seong Min Shin; Jwa-Jin Kim; Doo-Han Yoo; Hyung Don Kim; Sujin Kim; Minho Moon
• Keywords: Cognitive Decline; Pathogenesis; Amyloid beta

Alzheimer’s disease (AD) is a devastating neurodegenerative characterized by irreversible cognitive dysfunction. Amyloid beta (Aβ) peptide an important pathological factor that triggers the progression of AD through accumulation and aggregation, which leads to AD-related pathologies consequently affect functions. Interestingly, several studies have reported Platycodon grandiflorum root extract (PGE), besides exhibiting other bioactive effects, displays neuroprotective, anti-neuroinflammatory, cognitive-enhancing effects. However, date, it not clear whether PGE can dysfunction pathogenesis. Therefore, investigate influences impairment in animal model AD, we conducted Y-maze test using 5XFAD mouse model. Oral administration for 3 weeks at daily dose 100 mg/kg significantly ameliorated mice. Moreover, elucidate neurohistological mechanisms underlying PGE-mediated alleviative effect on dysfunction, performed histological analysis hippocampal formation these Histopathological showed alleviated such as Aβ accumulation, neurodegeneration, oxidative stress, neuroinflammation. In addition, observed neuroprotective antioxidant neurons. Our findings suggest might act one therapeutic agents decreasing related pathology ameliorating induced impairment.