Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings

• DOI: 10.3390/antiox10071126
• Publication Date: 2021-07-15T01:56:51Z
• Authors: Tijana Kosanovic; Dragan Sagic; Vladimir Djukic; Marija Pljesa-Erc...; Ana Savic-Radojevic; Zoran Bukumiric; Miodrag Lalosevic; Marjana Djordjevic; Vesna Coric; Tatjana Simic
• Keywords: Malondialdehyde

Although the original data on systemic oxidative stress in COVID-19 patients have recently started to emerge, we are still far from a complete profile of changes patients’ redox homeostasis. We aimed assess extent damage proteins, lipids and DNA during course acute disease, as well their association with CT pulmonary patterns. In order obtain more insight into origin stress, observed parameters were correlated inflammatory biomarkers multiorgan impairment. this prospective study, included 58 admitted between July October 2020 pneumonia. Significant malondialdehyde, 8-hydroxy-2’-deoxyguanosine advanced oxidation protein products levels exist COVID-19. Special emphasis should be placed fact that pattern differs non-hospitalized hospitalized individuals. Our results point time-dependent relation impairment biomarkers, patterns pneumonia patients. Correlation immunological or pattern, confirms suggested involvement neutrophils networks, IL-6 production, along different organ/tissue