Peroxisome Proliferator-Activated Receptor α Attenuates Hypertensive Vascular Remodeling by Protecting Vascular Smooth Muscle Cells from Angiotensin II-Induced ROS Production

• DOI: 10.3390/antiox11122378
• Publication Date: 2022-12-01T06:54:31Z
• Authors: Ye Liu; Yan Duan; Nan Zhao; Xinxin Zhu; Xiaoting Yu; Shiyu Jiao; Yanting Song; Li Shi; Yutao Ma; Xia Wang; Baoqi Yu; Aijuan Qu
• Keywords: Fibrate

Vascular remodeling is the fundamental basis for hypertensive disease, in which vascular smooth muscle cell (VSMC) dysfunction plays an essential role. Previous studies suggest that activation of peroxisome proliferator-activated receptor α (PPARα) by fibrate drugs has cardiovascular benefits independent lipid-lowering effects. However, underlying mechanism remains incompletely understood. This study explored role PPARα angiotensin II (Ang II)-induced and hypertension using VSMC-specific Ppara-deficient mice. The expression was markedly downregulated VSMCs upon Ang treatment. A deficiency VSMC significantly aggravated II-induced stiffness, with little influence on cardiac function. morphological analyses demonstrated mice exhibited oxidative stress. In vitro, a dramatically increased production mitochondrial reactive species (ROS) II-treated primary VSMCs. Finally, Wy14643 improved ROS PPARα-dependent manner. Taken together, these data critical protective via attenuating VSMCs, thus providing potential therapeutic target diseases.