Study of Ferroptosis Transmission by Small Extracellular Vesicles in Epithelial Ovarian Cancer Cells

• DOI: 10.3390/antiox12010183
• Publication Date: 2023-01-12T10:03:03Z
• Authors: Carmen Alarcón-Ve...; Rocío Mato-Basalo; Sergio Lucio-Gallego; Andrea Vidal-Pampín; María Quindós-Varela; Thamer Al-Qatarneh; Germán Berrecoso; Ángel Vizoso-Vázquez; María C. Arufe; Juan Fafián-Labora
• Keywords: epithelial ovarian cancer; 0301 basic medicine; ferroptosis; small extracellular vesicles; epithelial ovarian cancer; Small extracellular vesicles; RM1-950; Epithelial ovarian cancer; small extracellular vesicles; ferroptosis; Article; 3. Good health; 03 medical and health sciences; Ferroptosis; Therapeutics. Pharmacology

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of tumors followed by a combination chemotherapy. While patients achieve complete remission, many EOCs will recur and develop chemo-resistance. cells can adapt to several stress stimuli, becoming resistant. Because this, new ways fight resistant during disease are being studied. However, clinical outcomes remain unsatisfactory. Recently, ferroptosis, novel form regulated cell death trigged accumulation iron toxic species lipid metabolism in cells, has emerged as promising anti-tumor strategy treatment. This process high potential become complementary strategies eliminate avoid relapse. Cancer like other body, release small extracellular vesicles (sEV) that allow transport substances from themselves communicate with their environment. To we analyzed capacity epithelial (OVCA), treated ferroptosis inducers, generate sEV, assessing size number, study transmission sEV. Our results reveal OVCA ferroptotic inducers modify intercellular communication inducing recipient cells. Furthermore, these receptor able greater amount contributing much higher paracrine transmission. Thus, discovered importance sEV between OVCA, focusing on process. These findings could be beginning molecular mechanism through