Integrative Multiomics Profiling Unveils the Protective Function of Ulinastatin against Dextran Sulfate Sodium-Induced Colitis

• DOI: 10.3390/antiox13020214
• Publication Date: 2024-02-08T08:36:17Z
• Authors: Tianyu Yu; Jun Yan; Ruochen Wang; Lei Zhang; Xiake Hu; Jiaxi Xu; Fanni Li; Qi Sun
• Keywords: Dysbiosis; Ulinastatin

Ulcerative colitis is an inflammatory bowel disease with multiple pathogeneses. Here, we aimed to study the therapeutic role of ulinastatin (UTI), anti-inflammatory bioagent, and its associated mechanisms in treating colitis. Dextran sulfate sodium was administrated induce mice, a subgroup mice treated UTI. The gut barrier defect manifestations were determined via histological molecular experiments. In addition, transcriptomics, metagenomics, metabolomics employed explore possible underlying effects We found that UTI significantly alleviated intestinal damage Transcriptome sequencing revealed correlation between treatment JAK-STAT signaling pathway. up-regulated expression SOCS1, which subsequently inhibited phosphorylation JAK2 STAT3, thus limiting action mediators. 16S rRNA illustrated maintained more stable flora, protecting from dysbiosis Moreover, analysis demonstrated indeed facilitated production some bile acids short-chain fatty acids, supported homeostasis. Our data provide evidence effective support potential use for patients ulcerative