Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil

• DOI: 10.3390/antiox13080895
• Publication Date: 2024-07-24T19:47:32Z
• Authors: Cornelia-Ioana Ilie; Angela Spoiala; Cristina Chircov; Georgiana Dolete; Ovidiu-Cristian O...; Bogdan-Stefan Vasile; Simona Adriana Cr...; Adrian-Ionut Nicoara; Ioana Cristina Ma...; Miruna Silvia Stan; Lia-Mara Ditu; Anton Ficai; Eliza Oprea
• Keywords: Bee Pollen; Prebiotic

The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through spraying-assisted coprecipitation method, followed by loading bee pollen or bread extracts and an antitumoral (5-fluorouracil/5-FU). loaded-MNPs morphologically structurally characterized transmission electron microscopy (TEM), selected area diffraction (SAED), scanning (SEM), X-ray (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), thermogravimetric analysis. UV-Vis was applied establish release profiles antioxidant activity. Furthermore, antibacterial activity of assessed. results demonstrate with antioxidant, antibacterial, antiproliferative, prebiotic properties are obtained. Moreover, data highlight improvement 5-FU MNPs' surface synergistic effects between anticancer phenolic compounds (PCs). addition, prolonged behavior PCs many hours (70-75 h) after from developed advantage, at least point view PCs. Considering enhancement