Serum BDNF’s Role as a Biomarker for Motor Training in the Context of AR-Based Rehabilitation after Ischemic Stroke

• DOI: 10.3390/brainsci10090623
• Publication Date: 2020-09-09T13:01:09Z
• Authors: Ekaterina S. Koro...; Ivan V. Tolmachev; Valentina M. Alif...; Anastasiia S. Boiko; Lyudmila A. Levchuk; Anton J. M. Loonen; Svetlana A. Ivanova
• Keywords: Stroke

Background: brain-derived neurotrophic factor (BDNF) may play a role during neurorehabilitation following ischemic stroke. This study aimed to elucidate the possible of BDNF early recovery from stroke assisted by motor training. Methods: fifty patients were included after acute stroke: 21 first received classical rehabilitation followed ‘motor using motion sensors and augmented reality’ (AR-rehabilitation), 14 only AR-rehabilitation, 15 observed. Serum levels measured on day stroke, 14th day, before AR-based (median, 45th day), 82nd day). Motor impairment was quantified clinically Fugl–Meyer scale (FMA); functional disability activities daily living (ADL) Modified Rankin Scale (mRS). For comparison, serum in 50 healthy individuals. Results: found significantly increase phase with rehabilitation. The pattern sequentially similar treated patients. Untreated had lower at endpoint. Conclusions: fluctuations are not consistently related improvement but seem react active treatment. Without treatment, tends decrease.