Amino Acid Levels as Potential Biomarker of Elderly Patients with Dementia

• DOI: 10.3390/brainsci10120914
• Publication Date: 2020-11-27T14:16:49Z
• Authors: Edyta Socha; Piotr Kośliński; Marcin Koba; Katarzyna Mądra-G...; Kornelia Kędziora...; Marcin Gackowski; Emilia Daghir-Woj...
• Keywords: Pathogenesis

Dementia is a clinical syndrome characterized by cognitive impairment, in which there disturbance of multiple higher cortical functions. The primary risk factor dementia old age, and due to significant changes the worldwide demographic structure, prevalence impairment increasing dramatically with aging populations most countries. Alzheimer’s disease predominant leading cause dementia. aim this study was evaluate modifications amino acids that characterize initial stages help our understanding complex multifactorial pathogenesis neurodegenerative disorders. A total 123 participants were divided into two groups: healthy elderly subjects patients mild or moderate results indicate serum levels three changed significantly dementia, relation without In particular, we observed differences concentrations for serine, arginine isoleucine (all them increased compared control group). Our suggest metabolisms some seem be We conclude acid profiling might helpful better biochemical metabolic related progression However, considering multifactorial, heterogenous nature disease, validation greater sample further research required.