Low-Intensity Focused Ultrasound-Mediated Attenuation of Acute Seizure Activity Based on EEG Brain Functional Connectivity

• DOI: 10.3390/brainsci11060711
• Publication Date: 2021-05-27T15:07:02Z
• Authors: Minjian Zhang; Bo Li; Xiaodong Lv; Sican Liu; Yafei Liu; Rongyu Tang; Yiran Lang; Qiang Huang; Jiping He
• Keywords: Neuromodulation; Epileptic seizure

(1) Background: Ultrasound has been used for noninvasive stimulation and is a promising technique treating neurological diseases. Epilepsy common disorder, that attributed to uncontrollable abnormal neuronal hyperexcitability. Abnormal synchronized activities can be observed across multiple brain regions during seizure. (2) Methods: we low-intensity focused ultrasound (LIFU) sonicate the brains of epileptic rats, analyzed EEG functional network explore effect LIFU on network, continued mechanism neuromodulation. was in hippocampus rats which seizure induced by kainic acid. (3) Results: By comparing characteristics before after sonication, found significantly impacted especially low-frequency band. The connection strength decreased sonication compared control group. indicators (the path length, clustering coefficient, small-worldness, local efficiency global efficiency) all changed low-frequency. (4) Conclusions: These results revealed could reduce connections epilepsy circuits change structure at whole-brain level.