Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies

• DOI: 10.3390/brainsci12091194
• Publication Date: 2022-09-06T00:48:25Z
• Authors: Yi Piao; Ru Ma; Yaohao Weng; Chuan Fan; Xinzhao Xia; Wei Zhang; Ginger Qinghong Zeng; Yan Wang; Zhuo Lu; Jiangtian Cui; Xiaoxiao Wang; Li Gao; Bensheng Qiu; Xiaochu Zhang
• Keywords: Transcranial Direct Current Stimulation; Brain stimulation; Human brain

Temporal interference transcranial alternating current stimulation (TI-tACS) is a new technique of noninvasive brain stimulation. Previous studies have shown the effectiveness TI-tACS in stimulating areas selective manner. However, its safety modulating human neurons still untested. In this study, 38 healthy adults were recruited to undergo series neurological and neuropsychological measurements regarding concerns before after active (2 mA, 20/70 Hz, 30 min) or sham (0 0 TI-tACS. The included electroencephalography (EEG), serum neuron-specific enolase (NSE), Montreal Cognitive Assessment (MoCA), Purdue Pegboard Test (PPT), an abbreviated version California Computerized Package (A-CalCAP), revised Visual Analog Mood Scale (VAMS-R), self-assessment scale (SAS), questionnaire about adverse effects (AEs). We found no significant difference between groups. Meanwhile, serious intolerable reported observed group 19 participants. These results support that safe tolerable terms functions for use under typical electric (TES) conditions min).