High-Density Lipoprotein Correlates with Cognitive Functioning in Schizophrenic Women

• DOI: 10.3390/brainsci14070699
• Publication Date: 2024-07-12T20:23:41Z
• Authors: Maria Staniek; Pawel Kapelski; Przemyslaw Zakowicz; Aleksandra Rajews...; Karolina Wasicka-...; Maria Skibinska
• Keywords: schizophrenia; lipid profile; 03 medical and health sciences; 0302 clinical medicine; cognitive functions; low-density lipoprotein (LDL); positive and negative syndrome scale (PANSS); Neurosciences. Biological psychiatry. Neuropsychiatry; Wisconsin card sorting test (WCST); Article; RC321-571

(1) Background: Schizophrenia is a chronic and progressive neuropsychiatric illness. Apart from positive negative symptoms, 98% of the population diagnosed with schizophrenia have impaired cognitive functioning, which significantly influences quality life. The correlation between lipids functioning has been well established. Our study aimed to investigate correlations functions, severity lipid profiles. (2) Methods: Fifty-two women participated in this study. Cognitive was measured using Wisconsin Card Sorting Test (WCST). Positive Negative Symptom Scale (PANSS) used. serum profile, including low-density lipoproteins (LDLs), high-density (HDLs), triglycerides measured. (3) Results: Better functions were associated normal HDL levels, while low levels correlated worse WSCT scores. Only PANSS subscale showed levels. Correlations chronicity patient’s age poorer but not symptom severity, detected. Early/late at onset did influence (4) Conclusions: results suggest high might be protective factor against impairment. illness duration also play vital role performance.