Effect of Chronic Tibolone Administration on Memory and Choline Acetyltransferase and Tryptophan Hydroxylase Content in Aging Mice

• DOI: 10.3390/brainsci14090903
• Publication Date: 2024-09-06T11:42:06Z
• Authors: Tzayaka Castillo-...; Guadalupe Bautist...; Angélica Coyoy-Sa...; Emily L. Castillo...; Rodolfo Pinto-Alm...; Claudia Erika Fue...; Teresa Neri-Gómez; Christian Guerra-...
• Keywords: Tibolone; Tryptophan hydroxylase

Gonadal steroids exert different effects on the central nervous system (CNS), such as preserving neuronal function and promoting survival. Estradiol, progesterone, testosterone reduce loss in CNS animal models of neurodegeneration. However, hormone replacement therapy has been associated with higher rates endometrial, prostate, breast cancer. Tibolone (TIB), metabolites which show estrogenic progestogenic effects, is an alternative to this risk. impact TIB memory learning, well choline acetyltransferase (ChAT) tryptophan hydroxylase (TPH) levels hippocampus aging males, unknown. We administered aged C57BL/6J male mice at doses (0.01 or 1.0 mg/kg per day for 12 weeks) evaluated its learning content ChAT TPH. assessed object recognition elevated T-maze tasks. Additionally, we determined TPH protein by Western blotting. administration increased percentage time spent novel task. In addition, latency leaving enclosed arm both groups, suggesting improvement fear-based learning. also observed decreased group treated 0.01 dose. case TPH, no changes were either These results that long-term improves without affecting locomotor activity modulates cholinergic but not serotonergic systems mice.