Microbial Diversity and Pathogenic Properties of Microbiota Associated with Aerobic Vaginitis in Women with Recurrent Pregnancy Loss

• DOI: 10.3390/diagnostics12102444
• Publication Date: 2022-10-10T00:49:31Z
• Authors: Karima Ncib; Wael Bahia; Nadia Leban; Abdelkarim Mahdhi; Fatma Trifa; Ridha Mzoughi; Anis Haddad; Chédia Jabeur; Gilbert Donders
• Keywords: Dysbiosis; Vaginal flora; Pathogenic bacteria; Flora; Aerobic bacteria

Recurrent pregnancy loss (RPL) is a major reproductive problem that affects approximately 5% of couples. The objective this study was to assess vaginal flora dysbiosis in women suffering from unexplained RPL and investigate the pathogenic properties microbiota associated with aerobic vaginitis (AV). included one hundred fifteen women, 65 50 controls. diversity isolated evaluated by molecular sequencing. Then, factors, such as acid-resistance, antibiotics susceptibility, biofilm formation were evaluated. prevalence AV five-fold higher group than controls (64.6% vs. 12.0%). most prevalent isolates case Enterococcus spp. (52%) Staphylococcus (26%). All bacterial strains tolerate low pH. multidrug resistance (MDR) among all bacteria 47.7%. Of strains, 91.0% producers. presence MDR found be related formation. results provide evidence supporting an increased flora, especially AV, Tunisia. viability AV-associated their persistence genitals may due ability resist pH produce biofilm.