The Impact of Liquid Biopsies Positive for EGFR Mutations on Overall Survival in Non-Small Cell Lung Cancer Patients

• DOI: 10.3390/diagnostics13142347
• Publication Date: 2023-07-13T05:52:25Z
• Authors: Jonnathan Roldan ...; Marta Fuentes Gago; Luis Chinchilla T...; Idalia Gonzalez M...; José Sayagués; Mar Abad Hernández; Maria Cordovilla ...; Maria Ludeña de l...; Edel del Barco Mo...; Marta Rodriguez G...
• Keywords: Liquid biopsy; Univariate analysis

In recent years, non-small cell lung cancer treatment has been revolutionized. EGFR tyrosine kinase inhibitors and our improved understanding of its alterations have driven new diagnostic strategies. Liquid biopsies emerged as a useful tool in these contexts, showing potential utility early diagnosis combined with low-dose CT scans, well monitoring response predicting the development patients. We studied circulating tumor DNA (ctDNA) 38 EGFR-mutated patients at different moments their disease by liquid biopsy techniques. Our results show that mean overall survival was significantly lower when positive for detection mutations compared wild-type both univariate (29 ± 4 vs. 104 19 months; p = 0.004) multivariate analysis (p 0.008). Taking this into consideration, could be key to improving control disease.