The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis

• DOI: 10.3390/diagnostics14030340
• Publication Date: 2024-02-05T13:41:43Z
• Authors: Sara Sacchetti; Matteo Vidali; Teresa Esposito; Stefano Zorzi; Alessia Burgener; Lorenzo Ciccarello; Gianmaria Cammarota; Valentina Zanotti; Luca Giacomini; Mattia Bellan; Mario Pirisi; Ramon Simon Lopez; Umberto Dianzani; Rosanna Vaschetto; Roberta Rolla
• Keywords: Medicine (General); leukocyte parameter; 610; Article; sepsis; 03 medical and health sciences; Red Cell Distribution Width (RDW); R5-920; 0302 clinical medicine; early diagnosi; leukocyte parameters; morphological changes; morphological change; affordable health care; early diagnosis

Background: Late diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, available on the BC 6800 plus automated analyzer (Mindray) for the early detection of sepsis. Materials and Methods: A complete blood count (CBC) was performed by Mindray BC 6800 Plus Analyzer in 327 patients (223 with a confirmed diagnosis of sepsis following sepsis-3 criteria, 104 without sepsis), admitted at the Intensive Care Unit of the Novara’s Hospital (Italy) and in 56 patients with localized infection. Results: In univariate logistic regression, age, Hb, RDW, MO#, NMR, NeuX, NeuY, NeuZ, LymX, MonX, MonY, MonZ were associated with sepsis (p < 0.005). In multivariate analysis, only RDW, NeuX, NeuY, NeuZ, MonX and MonZ were found to be independent predictors of sepsis (p < 0.005). Morphological research parameters are confirmed to be predictors of sepsis even when analyzing the group with localized infection. Conclusions: In addition to already established biomarkers and basic CBC parameters, new morphological cell parameters can be a valuable aid in the early diagnosis of sepsis at no additional cost.