Effects of Soybean Meal Fermented by Lactobacillus plantarum NX69 on Growth Performance and Intestinal Health of Nursery Pigs

• DOI: 10.3390/fermentation11050235
• Publication Date: 2025-04-23T00:11:48Z
• Authors: Mengshi Zhao; Fengqiang Lin; Song Peng; Yaxiong Ma; Huini Wu; Zhaolong Li

The Intestinal system of nursery pigs is not fully matured and easily disturbed by dietary composition nutritional content. Probiotic-fermented feed has emerged as a beneficial form for widely utilized in the livestock poultry industries. However, there are limited reports regarding effects Lactobacillus plantarum-fermented on intestinal health growth performance pigs. In this study, we investigated effect plantarum NX69-fermented soybean multi-omics approaches results demonstrated that meal increased small villus height, height-to-crypt depth ratio (V/C), number goblet cells per unit length. Additionally, it enhanced mRNA mucosal barrier factors ZO-1, Occludin, Claudin Further research revealed diversity microbiota structure, elevated abundance core such Alloprevotella, Prevotellaceae, Megasphaera cecum, genera Megasphaera, Faecalibacterium, Ruminococcus, which known to produce short-chain fatty acids (SCFAs) cecum. Correlation analysis indicated were positively correlated with physical barriers, including length V/C ratio, well level Claudin. Furthermore, they differential metabolites Ginkgetin, Formiminoglutamic acid, Naringenin, Hydroxyisocaproic acid. These findings suggest can enhance increasing SCFAs then promoting improving performance, indicating promising application prospects.