Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives

• DOI: 10.3390/i8020070
• Publication Date: 2008-10-29T16:11:00Z
• Authors: Luiza Găină; Castelia Cristea; Claudia Moldovan; Dan Porumb; Emanoil Surducan; Calin Deleanu; Abdalah Mahamoud; Jacques Barbe; Ioan A. Silberg
• Keywords: Formylation; Quinoline; Smiles Rearrangement

Application of a dynamic microwave power system in the chemical synthesis ofsome phenothiazine and quinoline derivatives is described. Heterocyclic ring formation,aromatic nucleophilic substitution heterocyclic aldehydes/ketones condensationreactions were performed on solid support, or under solvent free reaction conditions. Themicrowave-assisted Duff formylation was achieved. Comparison ofmicrowave-assisted with conventional synthetic methods demonstratesadvantages related to shorter times some cases better yields.