Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development

• DOI: 10.3390/ijerph16081322
• Publication Date: 2019-04-12T16:55:04Z
• Authors: Po-Jen Yang; Ming-Ju Hsieh; Tung-Wei Hung; Shian-Shiang Wang; Shiuan-Chih Chen; Meng-Chih Lee; Shun-Fa Yang; Ying-Erh Chou
• Keywords: Adult; Male; Carcinoma, Transitional Cell; 0303 health sciences; H19; Middle Aged; Polymorphism, Single Nucleotide; Article; polymorphism; 3. Good health; 03 medical and health sciences; lncRNA; Urinary Bladder Neoplasms; urothelial cell carcinoma; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; RNA, Long Noncoding; Aged

Urothelial cell carcinoma (UCC) is one of the major malignancies genitourinary tract, and it induced by carcinogenic epidemiological risk factors. H19 most crucial long noncoding RNAs (lncRNAs) involved in various types bladder cancer. In this study, we examined single-nucleotide polymorphisms (SNPs) to investigate UCC susceptibility clinicopathological characteristics. Using real-time polymerase chain reaction, analyzed five SNPs 431 patients controls without The results showed that with carrying rs217727 CT + TT rs2107425 genetic variants had a high developing muscle invasive tumors (pT2–T4) (p = 0.030; p 0.025, respectively). With median follow up 39 months, CT+TT were associated worse disease-specific survival (adjusted hard ratio (AHR) 2.043, 95% confidence interval (CI) 1.029-4.059) aged older than 65 years. conclusion, our indicate have tumors. Thus, may be applied as marker or therapeutic target treatment.