The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

• DOI: 10.3390/ijms10073224
• Publication Date: 2009-07-16T06:57:24Z
• Authors: Magdalena Cieślik; Anna Mertas; Anna Morawska-Cho...; Daniel Sabat; Rajmund Orlicki; Aleksander Owczarek; Wojciech Król; Tadeusz Cieślik
• Keywords: 0301 basic medicine; Osteoblasts; Cell Survival; Biocompatible Materials; Mandible; 02 engineering and technology; Article; Carbon; 3. Good health; composites; PLGA co-polymer; carbon fibers; hydroxyapatite; human osteoblast-like cells; cytotoxicity; in vivo experiments on animals; biocompatibility; 03 medical and health sciences; Durapatite; Polylactic Acid-Polyglycolic Acid Copolymer; Carbon Fiber; Osseointegration; Animals; Humans; Lactic Acid; Rabbits; 0210 nano-technology; Cells, Cultured; Polyglycolic Acid

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible.