The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

• DOI: 10.3390/ijms10073224
• Publication Date: 2009-07-16T06:57:24Z
• Authors: Magdalena Cieślik; Anna Mertas; Anna Morawska-Cho...; Daniel Sabat; Rajmund Orlicki; Aleksander Owczarek; Wojciech Król; Tadeusz Cieślik
• Keywords: PLGA; Biocompatible material; Biodegradable polymer; Bone tissue

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of present work is a biological evaluation lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). cytotoxicity evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during one-year contact assessed living osseous tissue, progress bone formation analyzed accompanying process materials’ degradation evaluated. under proved be biocompatible.