The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

Osteoblasts Cell Survival Biocompatible Materials Mandible 02 engineering and technology Article Carbon 3. Good health composites; PLGA co-polymer; carbon fibers; hydroxyapatite; human osteoblast-like cells; cytotoxicity; in vivo experiments on animals; biocompatibility Durapatite Polylactic Acid-Polyglycolic Acid Copolymer Carbon Fiber Osseointegration Animals Humans Lactic Acid Rabbits 0210 nano-technology Cells, Cultured Polyglycolic Acid
DOI: 10.3390/ijms10073224 Publication Date: 2009-07-16T06:57:24Z
ABSTRACT
Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible.
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