Genetic Variants in the Apoptosis Gene BCL2L1 Improve Response to Interferon-Based Treatment of Hepatitis C Virus Genotype 3 Infection

• DOI: 10.3390/ijms16023213
• Publication Date: 2015-02-02T15:27:36Z
• Authors: Louise Clausen; Nina Weis; Steen Ladelund; Lone Madsen; Suzanne Lunding; Britta Tarp; Peer Christensen; Henrik Krarup; Axel Møller; Jan Gerstoft; Mette Clausen; Thomas Benfield; The DANHEP group
• Keywords: Adult; Male; 0301 basic medicine; Genotype; apoptosis in HCV treatment; bcl-X Protein; Apoptosis; Hepacivirus; Antiviral Agents; Polymorphism, Single Nucleotide; Article; Apoptosis in HCV treatment; 03 medical and health sciences; Drug Therapy; Prediction of sustained virological response; Humans; Polymorphism; Alleles; Genetic Variation; Single Nucleotide; Middle Aged; Viral Load; Hepatitis C; 3. Good health; Host genetics; Interferon and apoptosis interaction; Treatment Outcome; host genetics; interferon and apoptosis interaction; Combination; spontaneous HCV resolution; Drug Therapy, Combination; Female; prediction of sustained virological response; Interferons; Spontaneous HCV resolution

Genetic variation upstream of the apoptosis pathway has been associated with outcome hepatitis C virus (HCV) infection. We investigated genetic polymorphisms in intrinsic to assess their influence on sustained virological response (SVR) pegylated interferon-α and ribavirin (pegIFN/RBV) treatment HCV genotypes 1 3 infections. conducted a candidate gene association study prospective cohort 201 chronic HCV-infected individuals undergoing pegIFN/RBV. Differences between groups were compared logistic regression adjusted for age, viral load interleukin 28B genotypes. Four single nucleotide (SNPs) located B-cell lymphoma 2-like (BCL2L1) significantly SVR. SVR rates higher carriers beneficial rs1484994 CC In multivariate regression, SNP combined CC+TC 3.4 odds ratio (OR) genotype (p=0.02). The effect estimate was similar 1, but did not reach statistical significance. conclusion, anti-apoptotic SNPs BCL2L1 predictive pegIFN/RBV infected individuals. These may be used prediction SVR, further studies are needed.