Unsaturated Fatty Acids Affect Quorum Sensing Communication System and Inhibit Motility and Biofilm Formation of Acinetobacter baumannii

• DOI: 10.3390/ijms19010214
• Publication Date: 2018-01-10T17:41:10Z
• Authors: Marion Nicol; Stéphane Alexandre; Jean-Baptiste Luizet; Malena Skogman; Thierry Jouenne; Suzana Salcedo; Emmanuelle Dé
• Keywords: Acinetobacter baumannii; Homoserine

The increasing threat of Acinetobacter baumannii as a nosocomial pathogen is mainly due to the occurrence multidrug-resistant strains that are associated with real problem its eradication from hospital wards. particular ability this form biofilms contributes persistence, increases antibiotic resistance, and promotes persistent/device-related infections. We previously demonstrated virstatin, which small organic compound known decrease virulence Vibrio cholera via an inhibition T4-pili expression, displayed very promising activity prevent A. biofilm development. Here, we examined antibiofilm mono-unsaturated chain fatty acids, palmitoleic (PoA), myristoleic (MoA) presenting similar action on V. cholerae virulence. PoA MoA (at 0.02 mg/mL) were able ATCC 17978 formation up 38% 24%, respectively, presented dispersing effect drastically reduced motility. highlighted these acids decreased expression regulator abaR LuxIR-type quorum sensing (QS) communication system AbaIR consequently N-acyl-homoserine lactone production (AHL). This can be countered by addition exogenous AHLs. Besides, may have additional non-targeted effects, independent QS. Atomic force microscopy experiments probed indeed could also act initial adhesion process in modifying material interface properties. Evaluation 22 clinical isolates showed strain-dependent activity, was not correlated hydrophobicity or pellicle tested strains, suggested diversity cell-to-cell systems involved formation.