Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation

• DOI: 10.3390/ijms21031092
• Publication Date: 2020-02-07T08:13:27Z
• Authors: Nissrine Daou; Medhi Hassani; Emidio Matos; Gabriela Salim De...; Raquel Galvao Fig...; Marilia Seelaender; Viviana Moresi; Marco Rocchi; Sergio Adamo; Zhenlin Li; Onnik Agbulut; Dario Coletti
• Keywords: Muscle Atrophy

An idiopathic myopathy characterized by central nuclei in muscle fibers, a hallmark of regeneration, has been observed cancer patients. In cachexia skeletal is incapable consequently, this observation remains unaccounted for. C26-tumor bearing, cachectic mice, we fibers with the absence molecular markers bona fide regeneration. These clustered, non-peripheral were present NCAM-expressing fibers. Since NCAM expression upregulated denervated myofibers, searched for additional makers denervation, including AchRs, MUSK, and HDAC. This last one being also consistently muscles, correlated an increase myonuclei. held true musculature patients suffering from gastrointestinal cancer, where progressive number myonuclei was weight stable patients, compared to healthy subjects. Based on all above, presence animal models consistent motor neuron loss or NMJ perturbation could underlie previously neglected phenomenon rather than representing myofiber damage regeneration cachexia. Similarly aging, denervation-dependent atrophy contribute wasting