Comparative Analysis of Functional and Structural Decline in Retinitis Pigmentosas

• DOI: 10.3390/ijms21082730
• Publication Date: 2020-04-15T13:19:50Z
• Authors: Thiago Cabral; Jose Ronaldo Lima...; Joonpyo Kim; Jin Kyun Oh; Sarah R. Levi; Karen Sophia Park; Jimmy K. Duong; Junhyung Park; Katherine Boudreault; Rubens Belfort; Stephen H. Tsang
• Keywords: Electroretinography; Erg

Retinitis pigmentosa (RP) is a category of inherited retinal dystrophies that best prognosticated using electroretinography (ERG). In this retrospective cohort study 25 patients with RP, we evaluated the correlation between 30 Hz flicker ERG and structural parameters in retina. Internationally standardized recordings, short-wavelength autofluorescence (SW-AF), spectral domain–optical coherence tomography (SD-OCT) were acquired at two visits least one year apart. Vertical horizontal hyperautofluorescent ring diameter measurements SW-AF, as well ellipsoid zone (EZ) line width SD-OCT, used disease progression. The amplitude decreased by 2.2 ± 0.8 µV/year (p = 0.011), while implicit times remained unchanged. For EZ 204.1 34.7 µm/year < 0.001). Horizontal vertical diameters 161.9 25.6 146.9 34.6 µm/year, respectively 0.001), SW-AF. A was found progression rates recorded Burian–Allen electrodes both 0.020) 0.044). SW-AF readily available imaging techniques, may be to prognosticate because reliability their functional outcome.